Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients
Identifieur interne : 000856 ( Main/Exploration ); précédent : 000855; suivant : 000857Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients
Auteurs : Nikoletta B Di [Hongrie] ; Szabolcs Kéri [Hongrie] ; Helga Nagy [Hongrie] ; Ahmed Moustafa [États-Unis] ; Catherine E. Myers [États-Unis] ; Nathaniel Daw [États-Unis] ; György Dib [Hongrie] ; Annamária Takáts [Hongrie] ; Dániel Bereczki [Hongrie] ; Mark A. Gluck [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2009-09.
Abstract
Parkinson's disease is characterized by the degeneration of dopaminergic pathways projecting to the striatum. These pathways are implicated in reward prediction. In this study, we investigated reward and punishment processing in young, never-medicated Parkinson's disease patients, recently medicated patients receiving the dopamine receptor agonists pramipexole and ropinirole and healthy controls. The never-medicated patients were also re-evaluated after 12 weeks of treatment with dopamine agonists. Reward and punishment processing was assessed by a feedback-based probabilistic classification task. Personality characteristics were measured by the temperament and character inventory. Results revealed that never-medicated patients with Parkinson's disease showed selective deficits on reward processing and novelty seeking, which were remediated by dopamine agonists. These medications disrupted punishment processing. In addition, dopamine agonists increased the correlation between reward processing and novelty seeking, whereas these drugs decreased the correlation between punishment processing and harm avoidance. Our finding that dopamine agonist administration in young patients with Parkinson's disease resulted in increased novelty seeking, enhanced reward processing, and decreased punishment processing may shed light on the cognitive and personality bases of the impulse control disorders, which arise as side-effects of dopamine agonist therapy in some Parkinson's disease patients.
Url:
DOI: 10.1093/brain/awp094
Affiliations:
- Hongrie, États-Unis
- Hongrie centrale, New Jersey, État de New York
- Budapest, New Brunswick (New Jersey))
- Université Rutgers
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients</title><author><name sortKey="B Di, Nikoletta" sort="B Di, Nikoletta" uniqKey="B Di N" first="Nikoletta" last="B Di">Nikoletta B Di</name></author><author><name sortKey="Keri, Szabolcs" sort="Keri, Szabolcs" uniqKey="Keri S" first="Szabolcs" last="Kéri">Szabolcs Kéri</name></author><author><name sortKey="Nagy, Helga" sort="Nagy, Helga" uniqKey="Nagy H" first="Helga" last="Nagy">Helga Nagy</name></author><author><name sortKey="Moustafa, Ahmed" sort="Moustafa, Ahmed" uniqKey="Moustafa A" first="Ahmed" last="Moustafa">Ahmed Moustafa</name></author><author><name sortKey="Myers, Catherine E" sort="Myers, Catherine E" uniqKey="Myers C" first="Catherine E." last="Myers">Catherine E. Myers</name></author><author><name sortKey="Daw, Nathaniel" sort="Daw, Nathaniel" uniqKey="Daw N" first="Nathaniel" last="Daw">Nathaniel Daw</name></author><author><name sortKey="Dib, Gyorgy" sort="Dib, Gyorgy" uniqKey="Dib G" first="György" last="Dib">György Dib</name></author><author><name sortKey="Takats, Annamaria" sort="Takats, Annamaria" uniqKey="Takats A" first="Annamária" last="Takáts">Annamária Takáts</name></author><author><name sortKey="Bereczki, Daniel" sort="Bereczki, Daniel" uniqKey="Bereczki D" first="Dániel" last="Bereczki">Dániel Bereczki</name></author><author><name sortKey="Gluck, Mark A" sort="Gluck, Mark A" uniqKey="Gluck M" first="Mark A." last="Gluck">Mark A. Gluck</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9D4280556A5669CEA43493762EF381586A55F35A</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1093/brain/awp094</idno><idno type="url">https://api.istex.fr/document/9D4280556A5669CEA43493762EF381586A55F35A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001086</idno><idno type="wicri:Area/Main/Curation">000E93</idno><idno type="wicri:Area/Main/Exploration">000856</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients</title><author><name sortKey="B Di, Nikoletta" sort="B Di, Nikoletta" uniqKey="B Di N" first="Nikoletta" last="B Di">Nikoletta B Di</name><affiliation wicri:level="3"><country xml:lang="fr">Hongrie</country><wicri:regionArea>1 Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Keri, Szabolcs" sort="Keri, Szabolcs" uniqKey="Keri S" first="Szabolcs" last="Kéri">Szabolcs Kéri</name><affiliation wicri:level="3"><country xml:lang="fr">Hongrie</country><wicri:regionArea>1 Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hongrie</country></affiliation></author><author><name sortKey="Nagy, Helga" sort="Nagy, Helga" uniqKey="Nagy H" first="Helga" last="Nagy">Helga Nagy</name><affiliation wicri:level="3"><country xml:lang="fr">Hongrie</country><wicri:regionArea>2 Department of Neurology, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Moustafa, Ahmed" sort="Moustafa, Ahmed" uniqKey="Moustafa A" first="Ahmed" last="Moustafa">Ahmed Moustafa</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region><settlement type="city">New Brunswick (New Jersey))</settlement></placeName><orgName type="university">Université Rutgers</orgName></affiliation></author><author><name sortKey="Myers, Catherine E" sort="Myers, Catherine E" uniqKey="Myers C" first="Catherine E." last="Myers">Catherine E. Myers</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Department of Psychology, Rutgers University, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region><settlement type="city">New Brunswick (New Jersey))</settlement></placeName><orgName type="university">Université Rutgers</orgName></affiliation></author><author><name sortKey="Daw, Nathaniel" sort="Daw, Nathaniel" uniqKey="Daw N" first="Nathaniel" last="Daw">Nathaniel Daw</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Department of Psychology, Center for Neural Science, New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dib, Gyorgy" sort="Dib, Gyorgy" uniqKey="Dib G" first="György" last="Dib">György Dib</name><affiliation wicri:level="1"><country xml:lang="fr">Hongrie</country><wicri:regionArea>6 Albert Szent-Györgyi Clinical Center, Neurology Outpatient Unit, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Takats, Annamaria" sort="Takats, Annamaria" uniqKey="Takats A" first="Annamária" last="Takáts">Annamária Takáts</name><affiliation wicri:level="3"><country xml:lang="fr">Hongrie</country><wicri:regionArea>2 Department of Neurology, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Bereczki, Daniel" sort="Bereczki, Daniel" uniqKey="Bereczki D" first="Dániel" last="Bereczki">Dániel Bereczki</name><affiliation wicri:level="3"><country xml:lang="fr">Hongrie</country><wicri:regionArea>2 Department of Neurology, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Gluck, Mark A" sort="Gluck, Mark A" uniqKey="Gluck M" first="Mark A." last="Gluck">Mark A. Gluck</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region><settlement type="city">New Brunswick (New Jersey))</settlement></placeName><orgName type="university">Université Rutgers</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-09">2009-09</date><biblScope unit="volume">132</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="2385">2385</biblScope><biblScope unit="page" to="2395">2395</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">9D4280556A5669CEA43493762EF381586A55F35A</idno><idno type="DOI">10.1093/brain/awp094</idno><idno type="ArticleID">awp094</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Parkinson's disease is characterized by the degeneration of dopaminergic pathways projecting to the striatum. These pathways are implicated in reward prediction. In this study, we investigated reward and punishment processing in young, never-medicated Parkinson's disease patients, recently medicated patients receiving the dopamine receptor agonists pramipexole and ropinirole and healthy controls. The never-medicated patients were also re-evaluated after 12 weeks of treatment with dopamine agonists. Reward and punishment processing was assessed by a feedback-based probabilistic classification task. Personality characteristics were measured by the temperament and character inventory. Results revealed that never-medicated patients with Parkinson's disease showed selective deficits on reward processing and novelty seeking, which were remediated by dopamine agonists. These medications disrupted punishment processing. In addition, dopamine agonists increased the correlation between reward processing and novelty seeking, whereas these drugs decreased the correlation between punishment processing and harm avoidance. Our finding that dopamine agonist administration in young patients with Parkinson's disease resulted in increased novelty seeking, enhanced reward processing, and decreased punishment processing may shed light on the cognitive and personality bases of the impulse control disorders, which arise as side-effects of dopamine agonist therapy in some Parkinson's disease patients.</div></front></TEI><affiliations><list><country><li>Hongrie</li><li>États-Unis</li></country><region><li>Hongrie centrale</li><li>New Jersey</li><li>État de New York</li></region><settlement><li>Budapest</li><li>New Brunswick (New Jersey))</li></settlement><orgName><li>Université Rutgers</li></orgName></list><tree><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="B Di, Nikoletta" sort="B Di, Nikoletta" uniqKey="B Di N" first="Nikoletta" last="B Di">Nikoletta B Di</name></region><name sortKey="Bereczki, Daniel" sort="Bereczki, Daniel" uniqKey="Bereczki D" first="Dániel" last="Bereczki">Dániel Bereczki</name><name sortKey="Dib, Gyorgy" sort="Dib, Gyorgy" uniqKey="Dib G" first="György" last="Dib">György Dib</name><name sortKey="Keri, Szabolcs" sort="Keri, Szabolcs" uniqKey="Keri S" first="Szabolcs" last="Kéri">Szabolcs Kéri</name><name sortKey="Keri, Szabolcs" sort="Keri, Szabolcs" uniqKey="Keri S" first="Szabolcs" last="Kéri">Szabolcs Kéri</name><name sortKey="Nagy, Helga" sort="Nagy, Helga" uniqKey="Nagy H" first="Helga" last="Nagy">Helga Nagy</name><name sortKey="Takats, Annamaria" sort="Takats, Annamaria" uniqKey="Takats A" first="Annamária" last="Takáts">Annamária Takáts</name></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Moustafa, Ahmed" sort="Moustafa, Ahmed" uniqKey="Moustafa A" first="Ahmed" last="Moustafa">Ahmed Moustafa</name></region><name sortKey="Daw, Nathaniel" sort="Daw, Nathaniel" uniqKey="Daw N" first="Nathaniel" last="Daw">Nathaniel Daw</name><name sortKey="Gluck, Mark A" sort="Gluck, Mark A" uniqKey="Gluck M" first="Mark A." last="Gluck">Mark A. Gluck</name><name sortKey="Myers, Catherine E" sort="Myers, Catherine E" uniqKey="Myers C" first="Catherine E." last="Myers">Catherine E. Myers</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000856 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000856 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9D4280556A5669CEA43493762EF381586A55F35A
|texte= Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients
}}
| This area was generated with Dilib version V0.6.23. |  |